LGALS3

Across TCGA patient cohorts, LGALS3 protein abundance is significantly associated with the RNA expression of many other genes, with 14,736 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LGALS3-associated genes across cancer lineages are PGBD1, CAV1, and LYSMD1. Each is linked with LGALS3 in more than 5 cancer types. Because this analysis shows association rather than direction, both LGALS3-to-partner and partner-to-LGALS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGALS3 versus PGBD1 in LUAD, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS3→partner) and Y-score (partner→LGALS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PGBD1 →	-0.539	-0.365	.001	.002	3	6
GBM	CAV1 →	+1.105	+0.546	<.001	<.001	3	5
BRCA	LYSMD1 →	-0.634	-0.418	<.001	<.001	3	5
LSCC	ZNF74 →	-0.660	-0.349	<.001	<.001	3	5
UCEC	PRR3 →	-0.569	-0.470	<.001	.001	3	5
GBM	CAV2 →	+0.902	+0.581	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,736 associations by consensus.

LGALS3 vs PGBD1 — LUAD

Explore this scatter interactively →