LGALS3

Across TCGA patient cohorts, LGALS3 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGALS3-associated genes across cancer lineages are LINC02563, RNU6-992P, and RNU4-13P. Each is linked with LGALS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGALS3-to-partner and partner-to-LGALS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02563 grouped by LGALS3-low versus LGALS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS3→partner) and Y-score (partner→LGALS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC02563 →	+0.262	+4.005	<.001	.002	3	1
UCEC	RNU6-992P →	+0.213	+4.555	<.001	.005	3	1
UCEC	RNU4-13P →	+0.220	+4.727	<.001	.003	3	1
UCEC	SNORD114-18 →	+0.593	+3.884	<.001	.003	3	1
UCEC	MIR629 →	+0.360	+4.260	<.001	.007	3	1
UCEC	MIR100 →	+0.301	+4.923	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

LINC02563 by LGALS3 expression — UCEC

Explore this box plot interactively →