LGALS3

Across TCGA cell cohorts, LGALS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,370 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LGALS3-associated GO terms across cancer lineages are Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, Negative regulation of NK T cell activation, and Regulation of immunological synapse formation. Each is linked with LGALS3 in more than 18 cancer types. Because this analysis shows association rather than direction, both LGALS3-to-partner and partner-to-LGALS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell grouped by LGALS3-low versus LGALS3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS3→partner) and Y-score (partner→LGALS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell →	+2.183	+5.719	<.001	<.001	3	19
BONE	Negative regulation of NK T cell activation →	+1.154	+5.204	<.001	<.001	3	18
BONE	Regulation of immunological synapse formation →	+2.132	+5.719	<.001	<.001	3	16
STOMACH	Regulation of NK T cell activation →	+0.372	+3.396	<.001	.001	3	16
BREAST	Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell →	+0.296	+3.714	<.001	<.001	3	14
OVARY	Negative regulation of alpha-beta T cell activation →	+0.103	+4.074	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,370 associations by consensus.

Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell by LGALS3 expression — BONE

Explore this box plot interactively →