LGALS16

Across TCGA pan-cancer cohorts, LGALS16 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated LGALS16 data layer compared with 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LGALS16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LGALS16 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

COAD, LIHC, and KIRC are the cancer types where LGALS16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.405	0.798	<.001	66	view →
LIHC	DFS	Tertile	III,IV	0.076	0.360	.001	63	view →
KIRC	DFS	Tertile	III,IV	0.581	0.758	.003	60	view →
THYM	DFS	Tertile	All	0.679	0.917	.001	54	view →
CESC	OS	Tertile	III,IV	0.068	0.756	<.001	54	view →
ACC	DFS	Tertile	IV	0.079	0.427	.006	45	view →
UCEC	DFS	Tertile	All	0.638	0.848	<.001	42	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	27	view →
THCA	OS	Tertile	IV	0.520	0.857	.027	12	view →
PCPG	DFS	Tertile	All	0.768	0.935	.043	9	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
HNSC	DFS	Tertile	IV	0.737	0.320	.027	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

LGALS16–COAD (DFS)

Open the COAD breakdown →