LETMD1

Across TCGA patient cohorts, LETMD1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,866 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible LETMD1-associated genes across cancer lineages are ZNF484, GAB1, and NT5E. Each is linked with LETMD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LETMD1-to-partner and partner-to-LETMD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LETMD1 versus ZNF484 in BRCA, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LETMD1→partner) and Y-score (partner→LETMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF484 →	-0.640	-0.382	.003	.003	3	5
LUAD	GAB1 →	-0.645	-0.353	<.001	<.001	3	4
UCEC	NT5E →	-1.529	-0.306	.001	.005	3	4
BRCA	ANKRD50 →	-0.852	-0.430	.001	<.001	3	4
BRCA	ZNF654 →	-0.585	-0.455	.001	<.001	3	4
UCEC	SMIM7 →	-0.375	-0.380	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,866 associations by consensus.

LETMD1 vs ZNF484 — BRCA

Explore this scatter interactively →