LETMD1

Across TCGA patient cohorts, LETMD1 mutation is significantly associated with the RNA expression of many other genes, with 1,866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LETMD1-associated genes across cancer lineages are MIR4752, RPL12P18, and ATP13A5-AS1. Each is linked with LETMD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LETMD1-to-partner and partner-to-LETMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4752 grouped by LETMD1-low versus LETMD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LETMD1→partner) and Y-score (partner→LETMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4752 →	+0.093	+4.606	<.001	.001	3	2
BLCA	RPL12P18 →	+0.191	+3.054	<.001	.004	3	2
BLCA	ATP13A5-AS1 →	+0.206	+3.330	.003	.001	3	2
UCEC	FGF21 →	+0.297	+1.858	.004	.008	3	2
UCEC	MTUS2-AS1 →	+0.246	+1.979	<.001	.002	3	2
UCEC	LINC02641 →	+0.222	+2.270	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,866 associations by consensus.

MIR4752 by LETMD1 expression — UCEC

Explore this box plot interactively →