LETMD1

Across TCGA patient cohorts, LETMD1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LETMD1-associated genes across cancer lineages are Caspase-8, JNK_pT183_Y185, and JNK2. Each is linked with LETMD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LETMD1-to-partner and partner-to-LETMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by LETMD1-low versus LETMD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LETMD1→partner) and Y-score (partner→LETMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.262	-3.673	.009	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.169	-2.321	.012	.034	3	1
UCEC	JNK2 →	+0.284	+2.415	<.001	.003	3	1
UCEC	Ku80 →	+0.336	+2.428	<.001	.002	3	1
UCEC	Notch1 →	+0.154	+3.335	.006	.005	3	1
UCEC	p27_pT198 →	+0.108	+2.000	.011	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-8 by LETMD1 expression — UCEC

Explore this box plot interactively →