LETMD1

Across TCGA cell cohorts, LETMD1 mutation is significantly associated with the mutation status of many other genes, with 2,269 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LETMD1-associated genes across cancer lineages are MYO1D, AKAP1, and LRP8. Each is linked with LETMD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LETMD1-to-partner and partner-to-LETMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO1D grouped by LETMD1-low versus LETMD1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LETMD1→partner) and Y-score (partner→LETMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MYO1D →	+4.584	+4.584	.007	.007	1	3
CNS	AKAP1 →	+5.044	+5.614	.003	.003	1	3
CNS	LRP8 →	+5.044	+5.614	.003	.003	1	3
BLOOD_Lymphoma	GTF3C2 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Leukemia	PPM1G →	+6.321	+6.321	.001	.001	1	3
BLOOD_Leukemia	TMTC4 →	+4.321	+5.285	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,269 associations by consensus.

MYO1D by LETMD1 expression — BLOOD_Lymphoma

Explore this box plot interactively →