LETM2

Across TCGA patient cohorts, LETM2 mutation is significantly associated with the RNA expression of many other genes, with 2,789 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LETM2-associated genes across cancer lineages are MIR4445, RNU6-917P, and RNU6-289P. Each is linked with LETM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LETM2-to-partner and partner-to-LETM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4445 grouped by LETM2-low versus LETM2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LETM2→partner) and Y-score (partner→LETM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4445 →	+0.326	+7.731	<.001	.009	3	2
COAD	RNU6-917P →	+0.654	+4.993	<.001	.002	3	2
HNSC	RNU6-289P →	+0.361	+5.736	<.001	.003	3	2
UCEC	TRGJP2 →	+0.459	+2.303	<.001	<.001	3	2
UCEC	TRAJ11 →	+0.490	+1.983	<.001	.001	3	2
COAD	SNORD116-17 →	+0.346	+4.790	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,789 associations by consensus.

MIR4445 by LETM2 expression — BRCA

Explore this box plot interactively →