LETM2

Across TCGA cell cohorts, LETM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,545 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LETM2-associated GO terms across cancer lineages are Positive regulation of positive chemotaxis, Regulation of plasminogen activation, and Endoderm formation. Each is linked with LETM2 in more than 11 cancer types. Because this analysis shows association rather than direction, both LETM2-to-partner and partner-to-LETM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of positive chemotaxis grouped by LETM2-low versus LETM2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LETM2→partner) and Y-score (partner→LETM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of positive chemotaxis →	+0.323	+3.789	<.001	<.001	3	12
LIVER	Regulation of plasminogen activation →	+0.276	+1.835	<.001	.009	2	12
PANCREAS	Endoderm formation →	+0.143	+2.619	<.001	<.001	3	11
LIVER	Regulation of positive chemotaxis →	+0.326	+3.789	<.001	<.001	3	11
SKIN	Dentinogenesis →	+1.714	+0.883	<.001	<.001	3	11
STOMACH	Regulation of proteolysis →	+0.107	+1.974	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,545 associations by consensus.

Positive regulation of positive chemotaxis by LETM2 expression — LIVER

Explore this box plot interactively →