LETM1P2

Across TCGA pan-cancer cohorts, LETM1P2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of LETM1P2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where LETM1P2 RNA is repressed in tumor relative to normal tissue. In most cancer types LETM1P2 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and KICH are the cancer types where LETM1P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LETM1P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	−0.308	<.001	9	view →
THCA	Male	All	−0.306	<.001	8	view →
KICH	All	II,III,IV	−0.180	<.001	8	view →
KIRC	Male	II,III,IV	−0.142	<.001	8	view →
LIHC	All	All	+0.058	.001	5	view →
READ	Male	All	+0.026	.004	4	view →
ESCA	Female	All	−0.190	.038	2	view →
CHOL	All	All	+0.036	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

LETM1P2–KIRP

Open the KIRP breakdown →