LETM1

Across TCGA pan-cancer cohorts, LETM1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LETM1 data layer compared with 30 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LETM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LETM1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and LSCC are the cancer types where LETM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.891	.026	66	view →
LUAD	DFS	Median	All	0.981	0.816	.006	10	view →
LSCC	DFS	Median	All	0.515	0.936	.013	5	view →
CCRCC	DFS	Quartile	III,IV	0.074	0.740	.038	3	view →
PDAC	OS	Tertile	IV	0.472	0.934	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LETM1–COAD (DFS)

Open the COAD breakdown →