LETM1

Across TCGA patient cohorts, LETM1 RNA expression is significantly associated with the mutation status of many other genes, with 12,682 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LETM1-associated genes across cancer lineages are AHNAK, MUC16, and USH2A. Each is linked with LETM1 in more than 6 cancer types. Because this analysis shows association rather than direction, both LETM1-to-partner and partner-to-LETM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AHNAK grouped by LETM1-low versus LETM1-high in LUAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LETM1→partner) and Y-score (partner→LETM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AHNAK →	+3.746	+0.291	<.001	.004	3	7
LGG	MUC16 →	+1.852	+0.237	.002	.001	3	7
UCEC	USH2A →	+1.492	+0.358	<.001	<.001	3	7
CESC	FAT4 →	+1.815	+0.378	.007	.002	3	6
STAD	DOCK2 →	+2.395	+0.630	<.001	<.001	3	6
STAD	TENM3 →	+3.024	+0.415	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,682 associations by consensus.

AHNAK by LETM1 expression — LUAD

Explore this box plot interactively →