LETM1

Across TCGA patient cohorts, LETM1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LETM1-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and mTOR_pS2448. Each is linked with LETM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LETM1-to-partner and partner-to-LETM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by LETM1-low versus LETM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LETM1→partner) and Y-score (partner→LETM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.146	-1.700	.001	.042	3	2
UCEC	FOXO3a_pS318_S321 →	-0.148	-2.492	.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.150	-2.302	.007	.005	3	2
UCEC	p62 Lck ligand →	+0.587	+2.662	<.001	<.001	3	2
UCEC	PDCD4 →	-0.606	-2.169	<.001	.003	3	2
UCEC	ATM →	-0.527	-1.765	.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

A-Raf_pS299 by LETM1 expression — UCEC

Explore this box plot interactively →