LETM1

Across TCGA cell cohorts, LETM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,470 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LETM1-associated GO terms across cancer lineages are Regulation of transcription by RNA polymerase I, Regulation of aggrephagy, and Mitotic chromosome condensation. Each is linked with LETM1 in more than 17 cancer types. Because this analysis shows association rather than direction, both LETM1-to-partner and partner-to-LETM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription by RNA polymerase I grouped by LETM1-low versus LETM1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LETM1→partner) and Y-score (partner→LETM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of transcription by RNA polymerase I →	+0.129	+0.880	<.001	.004	3	18
BONE	Regulation of aggrephagy →	+0.134	+1.296	.002	<.001	3	17
BONE	Mitotic chromosome condensation →	+0.206	+1.372	.002	<.001	3	16
BREAST	Positive regulation of aggrephagy →	+0.137	+0.832	.003	.001	3	15
BONE	Transcription pausing by RNA polymerase II →	+0.147	+0.981	<.001	<.001	3	15
SOFT_TISSUE	Mitochondrial DNA metabolic process →	+0.112	+1.257	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,470 associations by consensus.

Regulation of transcription by RNA polymerase I by LETM1 expression — OESOPHAGUS

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