LETM1

Across TCGA cell cohorts, LETM1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LETM1-associated genes across cancer lineages are IQCF6, PSKH2, and KRTAP5-5. Each is linked with LETM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LETM1-to-partner and partner-to-LETM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by LETM1-low versus LETM1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LETM1→partner) and Y-score (partner→LETM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IQCF6 →	+0.141	+3.405	<.001	.005	3	2
SKIN	PSKH2 →	+0.018	+3.632	<.001	.003	3	1
SKIN	KRTAP5-5 →	+0.011	+4.022	<.001	.006	3	1
BLOOD_Leukemia	RIMS4 →	+0.200	+3.517	.002	.005	3	1
BLOOD_Leukemia	ADRA1A →	+0.112	+3.857	.003	<.001	3	1
BLOOD_Leukemia	BTBD16 →	+0.082	+2.959	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

IQCF6 by LETM1 expression — OVARY

Explore this box plot interactively →