LEPROTL1

Across TCGA patient cohorts, LEPROTL1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,245 significant associations in total. OV shows the largest number of these associations.

The most reproducible LEPROTL1-associated genes across cancer lineages are PVALB, GZMH, and XIAP. Each is linked with LEPROTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEPROTL1-to-partner and partner-to-LEPROTL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LEPROTL1 versus PVALB in OV, with a Pearson correlation of -0.93.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEPROTL1→partner) and Y-score (partner→LEPROTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PVALB →	-1.993	-1.063	<.001	.001	3	1
OV	GZMH →	-2.213	-1.110	<.001	.001	3	1
OV	XIAP →	+0.900	+0.917	.001	.002	3	1
OV	PCYT1B →	+0.827	+0.917	.009	.002	3	1
OV	HSDL1 →	+1.283	+1.103	.004	.001	3	1
OV	BLOC1S6 →	+0.807	+0.917	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,245 associations by consensus.

LEPROTL1 vs PVALB — OV

Explore this scatter interactively →