LEPROTL1

Across TCGA cell cohorts, LEPROTL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,341 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LEPROTL1-associated GO terms across cancer lineages are Negative regulation of growth hormone receptor signaling pathway, Late endosome to vacuole transport via multivesicular body sorting pathway, and Regulation of phosphatidylinositol dephosphorylation. Each is linked with LEPROTL1 in more than 8 cancer types. Because this analysis shows association rather than direction, both LEPROTL1-to-partner and partner-to-LEPROTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of growth hormone receptor signaling pathway grouped by LEPROTL1-low versus LEPROTL1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEPROTL1→partner) and Y-score (partner→LEPROTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of growth hormone receptor signaling pathway →	+0.145	+0.537	.001	.005	3	9
PANCREAS	Late endosome to vacuole transport via multivesicular body sorting pathway →	+0.082	+0.685	.001	.003	3	8
LUNG_SCLC	Regulation of phosphatidylinositol dephosphorylation →	+0.077	+0.549	.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	tRNA transcription by RNA polymerase III →	+0.091	+0.602	.004	.002	3	8
SOFT_TISSUE	Schwann cell differentiation →	+0.071	+0.445	<.001	.001	3	8
LARGE_INTESTINE	Endosome transport via multivesicular body sorting pathway →	+0.064	+0.779	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,341 associations by consensus.

Negative regulation of growth hormone receptor signaling pathway by LEPROTL1 expression — URINARY_TRACT

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