Across TCGA patient cohorts, LEPROT mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEPROT-associated genes across cancer lineages are RNA5SP408, RPL23AP90, and LINC01078. Each is linked with LEPROT in more than 1 cancer types. Because this analysis shows association rather than direction, both LEPROT-to-partner and partner-to-LEPROT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEPROT→partner) and Y-score (partner→LEPROT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP408 →	+0.354	+3.186	.005	.008	3	2
UCEC	RPL23AP90 →	+0.476	+3.004	<.001	.006	3	1
LUAD	LINC01078 →	+0.084	+7.930	<.001	.008	3	1
LUAD	LINC02791 →	+0.139	+7.930	<.001	.008	3	1
LUAD	RNU6-916P →	+0.288	+7.930	<.001	.008	3	1
LUSC	OR2T3 →	+0.043	+4.792	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

LEPROT survival (RNA) · tumor vs normal (RNA) · all LEPROT data types