Across TCGA cell cohorts, LEPROT RNA expression is significantly associated with the go_rna of many other GO terms, with 5,639 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LEPROT-associated GO terms across cancer lineages are Positive regulation of canonical NF-kappaB signal transduction, Oncostatin-M-mediated signaling pathway, and Response to interleukin-9. Each is linked with LEPROT in more than 15 cancer types. Because this analysis shows association rather than direction, both LEPROT-to-partner and partner-to-LEPROT results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEPROT→partner) and Y-score (partner→LEPROT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of canonical NF-kappaB signal transduction →	+0.068	+1.153	<.001	<.001	3	16
BONE	Oncostatin-M-mediated signaling pathway →	+0.258	+1.366	<.001	<.001	3	16
SOFT_TISSUE	Response to interleukin-9 →	+0.264	+0.993	<.001	<.001	3	15
BONE	Protein localization to vacuole →	+0.093	+1.405	<.001	<.001	3	15
BONE	Process utilizing autophagic mechanism →	+0.080	+1.400	<.001	<.001	3	14
BONE	Autophagy →	+0.080	+1.400	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,639 associations by consensus.

Exploration

LEPROT survival (RNA) · tumor vs normal (RNA) · all LEPROT data types