LEPR

Across TCGA pan-cancer cohorts, LEPR mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated LEPR data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LEPR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LEPR expression acts as an unfavorable survival marker.

LUAD and HNSC are the cancer types where LEPR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.833	0.956	.024	9	view →
HNSC	DFS	Median	II,III,IV	0.743	0.931	.022	7	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

LEPR–LUAD (DFS)

Open the LUAD breakdown →