LEPR

Across TCGA patient cohorts, LEPR RNA expression is significantly associated with the protein abundance of many other proteins, with 13,411 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LEPR-associated proteins across cancer lineages are SORBS1, CAVIN1, and OGN. Each is linked with LEPR in more than 6 cancer types. Because this analysis shows association rather than direction, both LEPR-to-partner and partner-to-LEPR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LEPR versus SORBS1 in BRCA, with a Pearson correlation of 0.65.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LEPR→partner) and Y-score (partner→LEPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SORBS1 →	+0.749	+0.907	<.001	<.001	3	7
BRCA	CAVIN1 →	+0.827	+1.043	<.001	<.001	3	7
UCEC	OGN →	+1.364	+1.007	<.001	<.001	3	7
BRCA	SBSPON →	+0.860	+0.768	<.001	<.001	3	6
BRCA	CAVIN3 →	+0.811	+1.088	<.001	<.001	3	6
BRCA	EHD2 →	+0.877	+1.008	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,411 associations by consensus.

LEPR vs SORBS1 — BRCA

Explore this scatter interactively →