LEPR

Across TCGA patient cohorts, LEPR mutation is significantly associated with the RNA expression of many other genes, with 6,540 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEPR-associated genes across cancer lineages are CDCA8, PGAM5, and BRF2. Each is linked with LEPR in more than 5 cancer types. Because this analysis shows association rather than direction, both LEPR-to-partner and partner-to-LEPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA8 grouped by LEPR-low versus LEPR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEPR→partner) and Y-score (partner→LEPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA8 →	+0.709	+4.290	<.001	<.001	3	6
UCEC	PGAM5 →	+0.652	+2.807	<.001	<.001	3	6
UCEC	BRF2 →	+0.522	+2.606	<.001	<.001	3	5
UCEC	OIP5 →	+0.929	+2.523	<.001	<.001	3	5
UCEC	NUSAP1 →	+0.823	+2.237	<.001	<.001	3	5
UCEC	MRPS18C →	+0.338	+2.949	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,540 associations by consensus.

CDCA8 by LEPR expression — UCEC

Explore this box plot interactively →