LEPR

Across TCGA cell cohorts, LEPR RNA expression is significantly associated with the go_rna of many other GO terms, with 5,394 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LEPR-associated GO terms across cancer lineages are Regulation of cell-substrate junction assembly, Regulation of focal adhesion assembly, and Regulation of programmed necrotic cell death. Each is linked with LEPR in more than 11 cancer types. Because this analysis shows association rather than direction, both LEPR-to-partner and partner-to-LEPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction assembly grouped by LEPR-low versus LEPR-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEPR→partner) and Y-score (partner→LEPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction assembly →	+0.170	+1.876	<.001	.001	3	12
BONE	Regulation of focal adhesion assembly →	+0.170	+1.876	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of programmed necrotic cell death →	+0.073	+0.997	.001	.002	3	11
SOFT_TISSUE	Maintenance of protein localization in organelle →	+0.139	+1.110	<.001	<.001	3	11
URINARY_TRACT	Response to hydrostatic pressure →	+0.130	+1.069	.003	.009	3	11
URINARY_TRACT	Regulation of protein exit from endoplasmic reticulum →	+0.128	+1.419	.001	.008	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,394 associations by consensus.

Regulation of cell-substrate junction assembly by LEPR expression — BONE

Explore this box plot interactively →