LEPR

Across TCGA cell cohorts, LEPR mutation is significantly associated with the RNA expression of many other genes, with 247 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LEPR-associated genes across cancer lineages are OR1L6, PNLIPRP3, and VPS4B. Each is linked with LEPR in more than 1 cancer types. Because this analysis shows association rather than direction, both LEPR-to-partner and partner-to-LEPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by LEPR-low versus LEPR-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEPR→partner) and Y-score (partner→LEPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR1L6 →	+0.020	+5.807	<.001	.001	3	2
LUNG_SCLC	PNLIPRP3 →	+0.012	+3.523	<.001	.008	3	2
LARGE_INTESTINE	VPS4B →	+0.683	+3.082	.003	.007	3	2
LARGE_INTESTINE	PEMT →	+0.551	+3.451	.004	.002	3	2
LARGE_INTESTINE	ELP3 →	+0.585	+3.364	.007	.002	3	2
LARGE_INTESTINE	FAM86B1 →	+1.222	+3.364	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 247 associations by consensus.

OR1L6 by LEPR expression — OVARY

Explore this box plot interactively →