LEP

Across TCGA patient cohorts, LEP mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEP-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and Annexin-1. Each is linked with LEP in more than 1 cancer types. Because this analysis shows association rather than direction, both LEP-to-partner and partner-to-LEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by LEP-low versus LEP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEP→partner) and Y-score (partner→LEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.233	-3.308	.008	.010	3	1
UCEC	Ku80 →	+0.340	+2.183	.006	.035	3	1
UCEC	Annexin-1 →	+0.729	+2.827	.008	.035	3	1
UCEC	Rictor_pT1135 →	-0.146	-3.321	.006	.010	3	1
UCEC	Caspase-8 →	-0.271	-3.000	.040	.036	3	1
UCEC	p62 Lck ligand →	+0.541	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK_pT183_Y185 by LEP expression — UCEC

Explore this box plot interactively →