LEP

Across TCGA cell cohorts, LEP mutation is significantly associated with the mutation status of many other genes, with 1,603 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LEP-associated genes across cancer lineages are NPTX2, GRB14, and IGFBP5. Each is linked with LEP in more than 1 cancer types. Because this analysis shows association rather than direction, both LEP-to-partner and partner-to-LEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPTX2 grouped by LEP-low versus LEP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEP→partner) and Y-score (partner→LEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NPTX2 →	+4.159	+5.215	<.001	<.001	1	2
LARGE_INTESTINE	GRB14 →	+3.422	+4.807	<.001	<.001	1	2
LARGE_INTESTINE	IGFBP5 →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	WRAP73 →	+5.744	+5.744	<.001	<.001	1	2
LARGE_INTESTINE	SSPN →	+3.744	+5.000	<.001	<.001	1	2
LARGE_INTESTINE	HOXC11 →	+3.007	+3.584	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,603 associations by consensus.

NPTX2 by LEP expression — LARGE_INTESTINE

Explore this box plot interactively →