LEO1

Across TCGA patient cohorts, LEO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,254 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LEO1-associated proteins across cancer lineages are RPUSD2, UBE3A, and USP8. Each is linked with LEO1 in more than 5 cancer types. Because this analysis shows association rather than direction, both LEO1-to-partner and partner-to-LEO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LEO1 versus RPUSD2 in COAD, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LEO1→partner) and Y-score (partner→LEO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPUSD2 →	+0.405	+0.535	.005	.003	3	6
BRCA	UBE3A →	+0.266	+0.627	<.001	<.001	3	6
BRCA	USP8 →	+0.282	+0.616	<.001	<.001	3	6
GBM	RTF1 →	+0.341	+0.346	<.001	<.001	3	6
GBM	DNAJC17 →	+0.350	+0.267	<.001	<.001	3	5
PDAC	AAGAB →	+0.310	+0.267	<.001	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,254 associations by consensus.

LEO1 vs RPUSD2 — COAD

Explore this scatter interactively →