LEO1

Across TCGA patient cohorts, LEO1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,190 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LEO1-associated genes across cancer lineages are SNRPE, VRK1, and RFC5. Each is linked with LEO1 in more than 6 cancer types. Because this analysis shows association rather than direction, both LEO1-to-partner and partner-to-LEO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LEO1 versus SNRPE in LSCC, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEO1→partner) and Y-score (partner→LEO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SNRPE →	+0.738	+0.263	<.001	<.001	3	7
HNSC	VRK1 →	+0.717	+0.139	<.001	<.001	3	6
LSCC	RFC5 →	+0.814	+0.329	<.001	<.001	3	6
HNSC	MBTD1 →	+0.616	+0.238	.001	<.001	3	6
LSCC	DARS2 →	+0.689	+0.349	<.001	<.001	3	6
GBM	CENPF →	+1.290	+0.355	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,190 associations by consensus.

LEO1 vs SNRPE — LSCC

Explore this scatter interactively →