LEO1

Across TCGA patient cohorts, LEO1 mutation is significantly associated with the RNA expression of many other genes, with 2,389 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEO1-associated genes across cancer lineages are FRG2GP, MIR4510, and MIR8053. Each is linked with LEO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEO1-to-partner and partner-to-LEO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRG2GP grouped by LEO1-low versus LEO1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEO1→partner) and Y-score (partner→LEO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	FRG2GP →	+0.133	+5.124	<.001	<.001	3	2
CESC	MIR4510 →	+0.236	+4.757	<.001	.004	3	2
CESC	MIR8053 →	+0.347	+4.757	<.001	.004	3	2
READ	DEFB132 →	+0.032	+5.925	<.001	.002	3	2
READ	RN7SL464P →	+0.153	+5.925	<.001	.002	3	2
COAD	RPL27P5 →	+0.234	+3.313	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,389 associations by consensus.

FRG2GP by LEO1 expression — CESC

Explore this box plot interactively →