LEO1

Across TCGA cell cohorts, LEO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,766 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LEO1-associated GO terms across cancer lineages are Transcription elongation by RNA polymerase II, Negative regulation of G2/M transition of mitotic cell cycle, and Negative regulation of cell cycle G2/M phase transition. Each is linked with LEO1 in more than 14 cancer types. Because this analysis shows association rather than direction, both LEO1-to-partner and partner-to-LEO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription elongation by RNA polymerase II grouped by LEO1-low versus LEO1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEO1→partner) and Y-score (partner→LEO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Transcription elongation by RNA polymerase II →	+0.087	+0.730	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of G2/M transition of mitotic cell cycle →	+0.071	+0.836	.002	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle G2/M phase transition →	+0.069	+0.930	.002	<.001	3	15
BLOOD_Myeloma	DNA-templated DNA replication maintenance of fidelity →	+0.090	+0.808	<.001	<.001	3	14
OESOPHAGUS	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.091	+0.728	<.001	<.001	3	13
KIDNEY	Positive regulation of chromosome condensation →	+0.201	+0.663	<.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,766 associations by consensus.

Transcription elongation by RNA polymerase II by LEO1 expression — SOFT_TISSUE

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