LEO1

Across TCGA cell cohorts, LEO1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LEO1-associated genes across cancer lineages are ECE2, CLEC4F, and DEFA4. Each is linked with LEO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEO1-to-partner and partner-to-LEO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by LEO1-low versus LEO1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEO1→partner) and Y-score (partner→LEO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.330	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	CLEC4F →	+0.246	+3.974	.001	.002	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.025	+4.353	<.001	.001	3	1
LARGE_INTESTINE	KRT73 →	+0.070	+3.196	<.001	.007	3	1
LARGE_INTESTINE	DCANP1 →	+0.011	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ECE2 by LEO1 expression — LARGE_INTESTINE

Explore this box plot interactively →