LENG9

Across TCGA patient cohorts, LENG9 mutation is significantly associated with the RNA expression of many other genes, with 1,379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LENG9-associated genes across cancer lineages are MIR3978, RNU6-1318P, and TRAJ57. Each is linked with LENG9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LENG9-to-partner and partner-to-LENG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3978 grouped by LENG9-low versus LENG9-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG9→partner) and Y-score (partner→LENG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3978 →	+0.252	+4.578	<.001	.005	3	2
UCEC	RNU6-1318P →	+0.381	+3.221	<.001	<.001	3	2
BLCA	TRAJ57 →	+0.692	+4.788	<.001	.006	3	2
UCEC	RNU4-65P →	+0.177	+3.338	<.001	.004	3	2
UCEC	RPS28P1 →	+0.103	+2.912	<.001	.009	3	2
COAD	RNU6-1113P →	+0.339	+7.741	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,379 associations by consensus.

MIR3978 by LENG9 expression — LUSC

Explore this box plot interactively →