LENG9

Across TCGA patient cohorts, LENG9 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LENG9-associated genes across cancer lineages are AMPK_pT172, STAT5a, and VHL. Each is linked with LENG9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LENG9-to-partner and partner-to-LENG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_pT172 grouped by LENG9-low versus LENG9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG9→partner) and Y-score (partner→LENG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AMPK_pT172 →	+0.468	+2.183	.029	.035	3	1
UCEC	STAT5a →	+0.416	+3.000	.047	.036	3	1
UCEC	VHL →	-1.051	-3.000	.003	.036	3	1
UCEC	MSH6 →	-0.533	-2.990	.002	.036	2	1
UCEC	Cyclin-B1 →	+0.658	+3.321	.025	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

AMPK_pT172 by LENG9 expression — UCEC

Explore this box plot interactively →