LENG9

Across TCGA cell cohorts, LENG9 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible LENG9-associated genes across cancer lineages are FAM181A, SERPINA12, and OPRPN. Each is linked with LENG9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LENG9-to-partner and partner-to-LENG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM181A grouped by LENG9-low versus LENG9-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG9→partner) and Y-score (partner→LENG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FAM181A →	+0.265	+5.000	<.001	.006	3	1
PANCREAS	SERPINA12 →	+0.016	+5.614	<.001	.002	3	1
PANCREAS	OPRPN →	+0.029	+5.000	<.001	.006	3	1
PANCREAS	USP17L3 →	+0.016	+5.000	<.001	.006	3	1
PANCREAS	ZNF728 →	+0.016	+5.000	<.001	.006	3	1
PANCREAS	MYH7 →	+0.006	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FAM181A by LENG9 expression — PANCREAS

Explore this box plot interactively →