LENG8

Across TCGA patient cohorts, LENG8 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LENG8-associated genes across cancer lineages are EGFR_pY1068, MSH6, and Cyclin-B1. Each is linked with LENG8 in more than 2 cancer types. Because this analysis shows association rather than direction, both LENG8-to-partner and partner-to-LENG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LENG8-low versus LENG8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG8→partner) and Y-score (partner→LENG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.308	-3.169	.016	.017	3	3
UCEC	MSH6 →	-0.275	-1.906	.008	.014	3	3
UCEC	Cyclin-B1 →	+0.531	+2.807	.002	.002	3	3
COAD	Lck →	+0.359	+3.321	.002	.009	3	3
UCEC	A-Raf_pS299 →	-0.123	-2.807	.001	.002	3	2
UCEC	ERK2 →	+0.219	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

EGFR_pY1068 by LENG8 expression — COAD

Explore this box plot interactively →