LENG1

Across TCGA patient cohorts, LENG1 mutation is significantly associated with the RNA expression of many other genes, with 274 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LENG1-associated genes across cancer lineages are TRAJ5, MIR6802, and PPP1R26P3. Each is linked with LENG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LENG1-to-partner and partner-to-LENG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ5 grouped by LENG1-low versus LENG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG1→partner) and Y-score (partner→LENG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ5 →	+1.477	+3.627	<.001	<.001	3	2
BLCA	MIR6802 →	+0.851	+6.618	<.001	.001	3	2
BRCA	PPP1R26P3 →	+0.011	+5.382	<.001	.003	3	1
BRCA	DEFB4B →	+0.149	+6.234	.007	<.001	3	1
BRCA	KRTAP20-2 →	+0.247	+5.382	<.001	.003	3	1
BRCA	RNU6-992P →	+0.471	+6.133	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 274 associations by consensus.

TRAJ5 by LENG1 expression — COAD

Explore this box plot interactively →