LENG1

Across TCGA patient cohorts, LENG1 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LENG1-associated genes across cancer lineages are Astrocytes, Macrophages, and Macrophages M1. Each is linked with LENG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LENG1-to-partner and partner-to-LENG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Astrocytes grouped by LENG1-low versus LENG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG1→partner) and Y-score (partner→LENG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Astrocytes →	+0.057	+2.107	<.001	.044	3	1
COAD	Macrophages →	+0.024	+2.440	.001	.019	3	1
COAD	Macrophages M1 →	+0.025	+2.834	.015	.035	3	1
UCEC	Mesangial cells →	-0.042	-2.983	.018	.036	3	1
COAD	Macrophages M2 →	+0.020	+2.834	.004	.035	1	2
UCEC	CD8+ naive T-cells →	+0.032	+1.917	.009	.030	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Astrocytes by LENG1 expression — COAD

Explore this box plot interactively →