LENG1

Across TCGA cell cohorts, LENG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,277 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LENG1-associated GO terms across cancer lineages are Regulation of telomere maintenance in response to DNA damage, Regulation of type B pancreatic cell development, and Negative regulation of calcium ion export across plasma membrane. Each is linked with LENG1 in more than 8 cancer types. Because this analysis shows association rather than direction, both LENG1-to-partner and partner-to-LENG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomere maintenance in response to DNA damage grouped by LENG1-low versus LENG1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG1→partner) and Y-score (partner→LENG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of telomere maintenance in response to DNA damage →	+0.116	+0.507	.001	.004	3	9
OVARY	Regulation of type B pancreatic cell development →	+0.154	+0.641	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.074	+0.567	<.001	.002	3	8
LARGE_INTESTINE	Positive regulation of intracellular transport →	+0.052	+0.489	.002	.003	3	8
SOFT_TISSUE	Organelle inheritance →	+0.086	+0.550	.002	<.001	3	7
SOFT_TISSUE	Golgi inheritance →	+0.086	+0.550	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,277 associations by consensus.

Regulation of telomere maintenance in response to DNA damage by LENG1 expression — URINARY_TRACT

Explore this box plot interactively →