LENG1

Across TCGA cell cohorts, LENG1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LENG1-associated genes across cancer lineages are GFRA4, NPHS2, and OR10W1. Each is linked with LENG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LENG1-to-partner and partner-to-LENG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by LENG1-low versus LENG1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG1→partner) and Y-score (partner→LENG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GFRA4 →	+0.022	+5.169	<.001	.005	3	1
LARGE_INTESTINE	NPHS2 →	+0.085	+4.252	<.001	<.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+3.240	.001	.004	3	1
LARGE_INTESTINE	OOSP3 →	+0.069	+3.285	.005	.007	3	1
LARGE_INTESTINE	MYO18B →	+0.500	+3.321	<.001	.007	2	1
LARGE_INTESTINE	NAA11 →	+0.309	+2.706	.005	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GFRA4 by LENG1 expression — BREAST

Explore this box plot interactively →