LEMD3

Across TCGA patient cohorts, LEMD3 mutation is significantly associated with the RNA expression of many other genes, with 3,701 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEMD3-associated genes across cancer lineages are RNA5SP414, LINC00373, and CYTH1P1. Each is linked with LEMD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEMD3-to-partner and partner-to-LEMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by LEMD3-low versus LEMD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEMD3→partner) and Y-score (partner→LEMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.405	+1.876	<.001	<.001	3	2
READ	LINC00373 →	+0.083	+4.925	<.001	.004	3	2
READ	CYTH1P1 →	+0.089	+4.937	<.001	.002	3	2
UCEC	TRAPPC5 →	+0.324	+2.458	<.001	.001	3	2
UCEC	NDUFA6 →	+0.498	+1.818	<.001	<.001	3	2
UCEC	EIF4EBP1 →	+0.438	+1.584	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,701 associations by consensus.

RNA5SP414 by LEMD3 expression — UCEC

Explore this box plot interactively →