LEMD3

Across TCGA cell cohorts, LEMD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,965 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LEMD3-associated GO terms across cancer lineages are Heterochromatin formation, Epigenetic regulation of gene expression, and Negative regulation of gene expression, epigenetic. Each is linked with LEMD3 in more than 17 cancer types. Because this analysis shows association rather than direction, both LEMD3-to-partner and partner-to-LEMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by LEMD3-low versus LEMD3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEMD3→partner) and Y-score (partner→LEMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Heterochromatin formation →	+0.079	+0.849	<.001	.001	3	18
STOMACH	Epigenetic regulation of gene expression →	+0.070	+0.978	.001	<.001	3	17
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.081	+0.821	<.001	<.001	3	17
LUNG_SCLC	Regulation of centrosome duplication →	+0.102	+0.631	<.001	<.001	3	16
SOFT_TISSUE	Negative regulation of cell cycle process →	+0.056	+1.144	<.001	<.001	3	16
LUNG_SCLC	Regulation of centrosome cycle →	+0.106	+0.773	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,965 associations by consensus.

Heterochromatin formation by LEMD3 expression — STOMACH

Explore this box plot interactively →