LEMD3

Across TCGA cell cohorts, LEMD3 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. CNS shows the largest number of these associations.

The most reproducible LEMD3-associated genes across cancer lineages are CFHR5, IL36A, and OR2M5. Each is linked with LEMD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEMD3-to-partner and partner-to-LEMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR5 grouped by LEMD3-low versus LEMD3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEMD3→partner) and Y-score (partner→LEMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CFHR5 →	+0.016	+3.449	<.001	.004	3	2
SOFT_TISSUE	IL36A →	+0.024	+4.930	.002	.008	3	1
SOFT_TISSUE	OR2M5 →	+0.019	+5.369	<.001	.004	3	1
SOFT_TISSUE	RPL10L →	+0.038	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR51I1 →	+0.648	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR51B6 →	+0.181	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

CFHR5 by LEMD3 expression — CNS

Explore this box plot interactively →