LEMD2

Across TCGA pan-cancer cohorts, LEMD2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LEMD2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LEMD2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LEMD2 is over-expressed in tumor, although a few such as OV show the opposite, repressed pattern.

HNSC, PDAC, and OV are the cancer types where LEMD2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LEMD2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.288	<.001	8	view →
PDAC	Male	II,III,IV	+0.390	<.001	6	view →
OV	All	All	−0.424	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

LEMD2–HNSC

Open the HNSC breakdown →