LEMD2

Across TCGA patient cohorts, LEMD2 mutation is significantly associated with the RNA expression of many other genes, with 190 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEMD2-associated genes across cancer lineages are MIR5584, OR10G6, and RNU6-970P. Each is linked with LEMD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LEMD2-to-partner and partner-to-LEMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5584 grouped by LEMD2-low versus LEMD2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEMD2→partner) and Y-score (partner→LEMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR5584 →	+0.458	+7.731	<.001	.009	3	3
UCEC	OR10G6 →	+0.026	+3.132	.008	.005	3	2
BLCA	RNU6-970P →	+0.263	+7.640	<.001	.009	3	2
UCEC	ATP5MGP8 →	+0.282	+2.606	.006	<.001	3	1
UCEC	MIR7702 →	+0.202	+4.060	<.001	.006	3	1
UCEC	MIR8055 →	+0.665	+2.584	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 190 associations by consensus.

MIR5584 by LEMD2 expression — BRCA

Explore this box plot interactively →