LEMD2

Across TCGA cell cohorts, LEMD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,393 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LEMD2-associated GO terms across cancer lineages are Endoplasmic reticulum to cytosol transport, Retrograde protein transport, ER to cytosol, and Skeletal muscle cell differentiation. Each is linked with LEMD2 in more than 15 cancer types. Because this analysis shows association rather than direction, both LEMD2-to-partner and partner-to-LEMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to cytosol transport grouped by LEMD2-low versus LEMD2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEMD2→partner) and Y-score (partner→LEMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Endoplasmic reticulum to cytosol transport →	+0.155	+0.865	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Retrograde protein transport, ER to cytosol →	+0.155	+0.865	<.001	<.001	3	15
STOMACH	Skeletal muscle cell differentiation →	+0.250	+0.832	<.001	<.001	2	16
KIDNEY	Phospholipid biosynthetic process →	+0.042	+0.627	.007	.001	3	15
BLOOD_Leukemia	Vacuole organization →	+0.039	+0.762	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Protein exit from endoplasmic reticulum →	+0.144	+0.897	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,393 associations by consensus.

Endoplasmic reticulum to cytosol transport by LEMD2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →