LEMD2

Across TCGA cell cohorts, LEMD2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LEMD2-associated genes across cancer lineages are PRAMEF20, OR2A2, and ITGAD. Each is linked with LEMD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEMD2-to-partner and partner-to-LEMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by LEMD2-low versus LEMD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEMD2→partner) and Y-score (partner→LEMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	2
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
BLOOD_Leukemia	MYF5 →	+0.013	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KCNA4 →	+0.052	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SPPL2C →	+0.012	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PRAMEF20 by LEMD2 expression — LARGE_INTESTINE

Explore this box plot interactively →