Across TCGA patient cohorts, LEMD1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEMD1-associated genes across cancer lineages are p27_pT157, ACC1, and Mre11. Each is linked with LEMD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEMD1-to-partner and partner-to-LEMD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEMD1→partner) and Y-score (partner→LEMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT157 →	-0.079	-2.960	.019	.036	3	1
UCEC	ACC1 →	+0.442	+3.000	.035	.036	2	1
UCEC	Mre11 →	-0.106	-3.000	.033	.037	2	1
UCEC	Rab11 →	-0.179	-3.000	.032	.037	2	1
UCEC	ACC_pS79 →	+0.523	+3.000	.009	.037	1	1
UCEC	p62 Lck ligand →	+0.401	+3.000	.033	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

LEMD1 survival (RNA) · tumor vs normal (RNA) · all LEMD1 data types