Across TCGA pan-cancer cohorts, LEMD1-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated LEMD1-AS1 data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher LEMD1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LEMD1-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and HNSC show a favorable association.

OV, KIRP, and HNSC are the cancer types where LEMD1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Quartile	II,III,IV	0.896	0.759	<.001	104	view →
KIRP	DFS	Quartile	II,III,IV	0.319	0.806	<.001	73	view →
HNSC	DFS	Quartile	All	0.777	0.647	.004	69	view →
LGG	OS	Median	All	0.355	0.531	<.001	54	view →
DLBC	OS	Median	All	0.473	0.960	.002	44	view →
KIRC	DFS	Quartile	II,III,IV	0.297	0.621	<.001	38	view →
READ	DFS	Median	All	0.723	0.893	.001	36	view →
ESCA	OS	Quartile	III,IV	0.831	0.223	<.001	33	view →
LIHC	DFS	Tertile	II,III,IV	0.439	0.171	.007	31	view →
COAD	DFS	Median	All	0.394	0.615	.001	29	view →
STAD	DFS	Median	III,IV	0.676	0.504	.002	27	view →
BLCA	DFS	Tertile	IV	0.308	0.611	.020	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

Exploration

Same gene, other analysis: LEMD1-AS1 tumor-vs-normal RNA expression · all LEMD1-AS1 data types