Across TCGA patient cohorts, LEKR1 protein abundance is significantly associated with the RNA expression of many other genes, with 544 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LEKR1-associated genes across cancer lineages are KLK6, MYL12A, and SMPD3. Each is linked with LEKR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEKR1-to-partner and partner-to-LEKR1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEKR1→partner) and Y-score (partner→LEKR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KLK6 →	-2.538	-1.208	.002	<.001	3	2
COAD	MYL12A →	-0.790	-0.893	<.001	.007	3	1
COAD	SMPD3 →	+0.780	+0.676	.005	.003	3	1
COAD	SHD →	+0.650	+0.936	.003	.003	3	1
COAD	CAV2 →	-1.415	-1.078	.001	<.001	3	1
COAD	PTPRZ1 →	-0.410	-0.749	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 544 associations by consensus.

Exploration

LEKR1 survival (RNA) · tumor vs normal (RNA) · all LEKR1 data types